maybe on some occasionóHave you ever heard of the mediterranean feveránea, but you don't really know whaté It consists. to get started, It must be taken into account that it is a autoinflammatory disorder geneético, what causes persistent fever and serositis, that is to say, inflammationón painful in the abdomen, the tórax and joints. In general, the demonstrationsíonly begin during childhood, but the diagnosisóstic is often not realized until adulthood.
Index
¿Whoseén does Mediterranean fever affectánea?
Mediterranean feveránea is a mental disorderáhereditary carórecessive monkey, which means that both genes in a pair must be abnormal for thisí se dé origin of the disease. In this way, those people who only have one defective gene are considered carriers. Many times, these people do not have the disease but can pass on an abnormal gene to their children.
Causes of Mediterranean feveránea
Mediterranean feveránea is caused by a mutationón genéethics that is transmitted from parents to children, a mutationón that is produced in the gene called MEFV and that encodes the proteinína pirina. Some mutations can cause very serious cases, while in other cases we find that the sísymptoms and signs are más leves.
Sísymptoms of Mediterranean feveránea
In regards to the sísymptoms of Mediterranean feveránea, keep in mind that, as a general rule, the great majoría of the signs and sísymptoms begin during childhood, when they occur “attacks” of fever, serositis, arthritis y erythema cutáneo with duración one to three días.
People who suffer from this disease may have the following symptoms:íntomas:
- Fever
- Chest pain
- Abdominal pain and stressñmentation
- Pain is inflammationónumber of joints (the MáThe knees are frequently affected., the hips, elbows and ankles).
- Rash on the legs, especially below the knees.
- Muscle pains.
- Headache.
- Inflammationón and tenderness in the scrotum.
Between one attack and another, it is likely that the person does not present síntomas. The periods in which they do not appearíSymptoms can vary from as little as two daysíseveral weeks.
Complications of Mediterranean feveránea
If Mediterranean feveránea is not treated, Different complications can arise in those who suffer from this health problem, What:
- amyloidosis: The body may produce a proteiníabnormal temperature while attacks of Mediterranean fever occuránea, which can accumulate in the body and cause damageñthe orgánico, could affect the riñones and causes síndrome nefrótico. It is úlast can cause coáthroats of bloodíneos in the riversñones or kidney failure.
- sterility in women: The inflammationón causes tooén can affect the ófemale genital organs and cause sterility in these, with what it entails.
Diagnóstic of mediterranean feveránea
The diagnosisóstic of mediterranean feveránea is mainly clíunique and the tests areán indicated to support it, especially the gene studyético. It is important to collect informationóno how:
- demonstrations clíunique and explorationón física.
- Revisionón of the preceding méfamily records.
- Anáblood lysis: During an attack the anáBlood lysis can show elevated levels of some markers that reveal an inflammatory disorder in the body.
- Análysis genéticos: This can determine if the MEFV gene has a mutation.ón linked to Mediterranean feveránea. Los análisis genéticos, nevertheless, have not managed to evolve enough to check all the gene mutationsérelated ethics, what can cause false negatives. Thus, only be requestedán in those patients who do not present síntomas tíspikes or respond to usual treatment.
Treatment of Mediterranean feveránea
In this sense, you have to be clear that There is no cure for Mediterranean feveránea, although yesí that there is treatment focused on trying to prevent outbreaks and the complications that they can generate in the long term.
For this, the use of some medications such as:
- colchicine: reduce inflammationóno of the body, helps prevent attacks and prevents amyloidosis. Nevertheless, can cause some common side effects, including diarrhea, abdominal pain and a distended abdomen.
- Anti-ILI: In the case of people whose signs and sísymptoms not controlled with colchicine, it is possible to use medications that are responsible for blocking the proteiníon interleukin-I, and that is part of the inflammationón. These drugs include rilonacept, anakinra y canakinumab.
Currently, the pronóstatic of patients suffering from Mediterranean feveránea is favorable, something that has to do with advances in treatment and secondary amyloidosis occurs very rarely. Thus, as a general rule, patients suffering from this problem They usually submit a referralón clínica, being able to enjoy a good quality of life.
Nevertheless, It should be noted that sometimes, although they are the least, some people may develop kidney failure, with the need to be subjected to diákidney lysis or transplant.
Anyway, we find that, just like any other disease, so that the patient can have a better prognosisóaesthetic and can improve your quality of life, early diagnosis is essential, since in this way you caná carry out the corresponding treatment more promptly, además to have greater control over sísymptoms that it may cause to the affected people.
It is therefore very important to have control over the májust smallñyou from the house, since it must be taken into account that the manifestations clíUnique symptoms usually begin during this phase of childhood, although on many occasions they go somewhat unnoticed until the diagnosis occurs.óstic when they are already adults. Realizing the problem and being able to diagnose it from an early age will helpá to improve the forecastóaesthetic of all the people who are affected by it, and although there is no definitive cure for Mediterranean feveránea, sí You have to be aware that with appropriate medications you can minimize the risks.ísymptoms and, Thus, help improve quality of life.
